BBB: excluded
- Minimal clinically meaningful CNS entry
- Polarity/charge or active efflux may exclude drug
- Peripheral effects dominate
- CNS adverse effects are generally reduced
- Barrier failure can occasionally change exposure
Interaction at a glance
- Minimal clinically meaningful CNS entry
Mechanism
- Minimal clinically meaningful CNS entry
- Polarity/charge or active efflux may exclude drug
- Peripheral effects dominate
Clinical consequence
- Barrier failure can occasionally change exposure
Management
- CNS adverse effects are generally reduced
Self-check
- Key clinical effect of BBB: excluded?
CNS adverse effects are generally reduced. - What can occasionally change CNS exposure despite BBB exclusion?
Barrier failure.
Drugs in this interaction (262)
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