Conivaptan
VAPRISOL
What it isDual V1a and V2 vasopressin antagonist; euvolemic and hypervolemic hyponatremia.
Why this oneIntravenous aquaresis raises sodium without a fluid load.
What limits itIt must not correct sodium too fast — osmotic demyelination. IV only, and a strong CYP3A4 inhibitor.
FDA-approved for
- hyponatremia (2005)
NO BOXED WARNINGS
Principal riskToo-rapid sodium correction; a strong CYP3A4 inhibitor
Classes and tags
Clinical profile
Mechanism of action: Conivaptan ballicule
