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Hexamethonium

C6

What it isGanglionic nicotinic blocker; historical antihypertensive.

Why this oneIt demonstrated that blood pressure could be lowered pharmacologically at all.

What limits itBlocking both autonomic limbs caused intolerable effects. Of historical interest only.

NO BOXED WARNINGS

Principal riskBlocking both autonomic limbs caused intolerable effects

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Hexamethonium ballicule

Hexamethonium ballicule: receptor binding, kinetics and half-life diagram

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