Methicillin
historical
What it isPenicillinase-resistant penicillin; withdrawn.
Why this oneIt gave the name to methicillin-resistant Staphylococcus aureus, which is its only remaining significance.
What limits itInterstitial nephritis ended its use; oxacillin and nafcillin replaced it. Susceptibility is still reported as methicillin-sensitive or resistant.
FDA-approved for
- staphylococcal infections (1960)
NO BOXED WARNINGS
Principal riskWithdrawn for interstitial nephritis
Classes and tags
Clinical profile
Mechanism of action: Methicillin ballicule
