Fexofenadine
ALLEGRA
What it isSecond-generation H1 antagonist and P-gp substrate; allergic rhinitis and urticaria.
Why this oneIt is actively excluded from the CNS by P-gp, making it the least sedating antihistamine.
What limits itFruit juice reduces absorption substantially through OATP inhibition. Cations block it; renally adjusted.
FDA-approved for
- allergy (1996)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Allergy relief | ≥12 yr | 18 mg QD | 1 tablet/24h |
Renal Undefined
Hepatic Undefined
Instructions
- Take with water.
- Do not take more than 1 tablet in 24 hours.
- Children under 12: do not use.
- Adults 65 and older: ask a doctor.
Pregnancy Undefined
Lactation Undefined
NO BOXED WARNINGS
Principal riskFruit juice substantially reduces absorption
Classes and tags
Clinical profile
Mechanism of action: Fexofenadine ballicule
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