Clotrimazole

LOTRIMIN

What it isImidazole CYP51 inhibitor; tinea and cutaneous, vulvovaginal or oropharyngeal candidiasis.

Why this oneIt spans OTC skin and vaginal products plus prescription oral troches, an unusually broad set of local formulations.

What limits itTroches can raise tacrolimus exposure despite minimal absorption; local burning occurs, and no form treats invasive disease.

FDA-approved for

FDA dosing	Population	Start	Target	Max
Athlete's foot / ringworm	Adult (supervise children)	Apply thin layer BID (AM & PM)	Apply thin layer BID x4 weeks
Jock itch	Adult (supervise children)	Apply thin layer BID (AM & PM)	Apply thin layer BID x2 weeks

Renal Undefined

Hepatic Undefined

Athlete's foot/ringworm: 4-week course; jock itch: 2-week course

Wash and dry the affected area thoroughly before applying
Athlete's foot/ringworm: use daily for 4 weeks; jock itch: use daily for 2 weeks
Not effective on the scalp or nails
Supervise children's use; if condition persists longer than the course, ask a doctor

Discontinue and consult a doctor if the condition persists beyond the treatment course

Pregnancy Undefined

Lactation Undefined

NO BOXED WARNINGS

Principal riskLittle; topical

Cost, est. cash$10–$300/month

Generic entry1993

Therapeutic safety burden1 / 4

Overdose danger0 / 4

Weight-gain liability0 / 4

Sedation liability0 / 4

QT / Torsades0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk0 / 4

Legacy pregnancy categoryC

Defining liabilityLocal irritation or hypersensitivity; systemic toxicity is minimal with correct local use.