Substance P
endogenous
What it isEndogenous tachykinin acting at the NK1 receptor.
Why this oneThe ligand whose blockade by aprepitant prevents delayed chemotherapy nausea.
What limits itNK1 antagonists have repeatedly failed as analgesics despite substance P’s role in nociception.
NO BOXED WARNINGS
Principal riskNK1 antagonists have repeatedly failed as analgesics despite substance P’s role in nociception
Classes and tags
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Self-check
- Which receptor does substance P activate?
NK1. - What nausea does aprepitant prevent by blocking substance P’s action?
Delayed chemotherapy nausea.