GABA
What it isThe principal inhibitory neurotransmitter, acting at GABA-A, GABA-B and GABA-C receptors.
Why this oneBenzodiazepines, barbiturates, alcohol, propofol and neurosteroids all converge on GABA-A, each at a different site.
What limits itOral GABA supplements do not cross the blood-brain barrier meaningfully, which is why they do nothing.
NO BOXED WARNINGS
Principal riskOral supplements do not cross the blood-brain barrier
