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Gamma- Aminobutyric Acid

GABA

What it isThe principal inhibitory neurotransmitter, acting at GABA-A, GABA-B and GABA-C receptors.

Why this oneBenzodiazepines, barbiturates, alcohol, propofol and neurosteroids all converge on GABA-A, each at a different site.

What limits itOral GABA supplements do not cross the blood-brain barrier meaningfully, which is why they do nothing.

NO BOXED WARNINGS

Principal riskOral supplements do not cross the blood-brain barrier

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Gamma- Aminobutyric Acid ballicule

Gamma- Aminobutyric Acid ballicule: receptor binding, kinetics and half-life diagram

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