Capsaicin
QUTENZA
What it isTRPV1 agonist causing nociceptor defunctionalization; neuropathic pain.
Why this oneThe 8% patch gives months of relief from a single application by depleting nerve terminals.
What limits itIntense burning during application requires pre-treatment and supervised administration. Benefit takes weeks to appear.
FDA-approved for
- neuropathic pain (2009)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Topical analgesic (minor aches/pains) | Adults & children ≥12 yr | Apply to affected area | 3–4 times daily |
Renal Undefined
Hepatic Undefined
Instructions
- Apply to affected area; children <12 yr ask a doctor
Pregnancy Undefined
Lactation Undefined
NO BOXED WARNINGS
Principal riskIntense burning during application
Classes and tags
Clinical profile
Mechanism of action: Capsaicin ballicule
