Leptin
endogenous
What it isAdipocyte hormone signaling energy sufficiency.
Why this oneIts discovery predicted an obesity cure; instead common obesity turned out to be leptin-RESISTANT.
What limits itHence replacement works only in true congenital deficiency and lipodystrophy.
NO BOXED WARNINGS
Principal riskCommon obesity is leptin-resistant, so replacement does nothing
Classes and tags
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Self-check
- Why did leptin replacement fail as a general obesity treatment?
Common obesity is leptin-resistant. - Where does leptin replacement work?
True congenital deficiency and lipodystrophy.