D-Serine
NMDA co-agonist
What it isD-serine, the principal endogenous co-agonist at the NMDA glycine site.
Why this oneThe channel cannot open without it, which is why glycine-site drugs and D-amino acid oxidase inhibitors are pursued in schizophrenia.
What limits itNephrotoxicity at high doses in animals has limited direct supplementation.
NO BOXED WARNINGS
Principal riskNephrotoxicity at high doses in animals
Classes and tags
Clinical profile
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Self-check
- At which NMDA site is D-serine a co-agonist?
The glycine site. - What toxicity limited direct high-dose D-serine supplementation in animals?
Nephrotoxicity.