Narrow therapeutic index (NTI)
- Small exposure change can alter efficacy/toxicity
- Dose, adherence + DDIs matter disproportionately
- Some require serum-level monitoring
- Formulation/brand changes may matter
- Treat PK changes as clinically important
Class at a glance
- Small exposure change can alter efficacy/toxicity
Practical pearls
- Dose, adherence + DDIs matter disproportionately
Clinical role
- Formulation/brand changes may matter
- Treat PK changes as clinically important
Safety / monitoring
- Some require serum-level monitoring
Self-check
- What monitoring do some NTI drugs require?
Serum levels. - Can formulation or brand changes matter for NTI drugs?
Yes.
Drugs in this class (210)
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