Desmethyl clomipramine
clomipramine metabolite
What it isThe N-desmethyl metabolite of clomipramine, markedly more noradrenergic than the parent.
Why it mattersIt shifts a clomipramine dose from serotonergic toward noradrenergic as it accumulates, which matters in OCD where serotonergic effect is what works.
What it changesCYP2D6 poor metabolizers accumulate the parent and less metabolite, so their profile is more serotonergic and more anticholinergic.
FDA-approved for
- OCD (metabolite of clomipramine)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Mechanism of action: Desmethyl clomipramine ballicule
