Serotonin reuptake inhibitor
- ↑ extracellular serotonin
- Inhibits serotonin transporter (SERT)
- Antidepressant, anxiolytic and anti-obsessional effects
- Sexual dysfunction, GI effects and early activation
- With MAO inhibition → high serotonin-toxicity risk
- Gillman: only two TCAs with substantial SRI potency
- clomipramine (ANAFRANIL), imipramine (TOFRANIL)
- Serotonicity — how much a drug raises synaptic serotonin; distinction from “serotonergic”
Drugs with this mechanism (59)
8-OH-Amoxapine
Amitriptyline
Amoxapine
Atomoxetine
Brompheniramine
Centanafadine
Chlorpheniramine
Chlorpromazine
Chlorpromazine injection
Citalopram
Clomipramine
Cocaine
Desipramine
Desmethylclomipramine
Desmethylsertraline
Desvenlafaxine
Dextromethorphan
Dextrorphan
Doxepin
Duloxetine
Venlafaxine XR
Escitalopram
Fentanyl
Fluoxetine
Fluvoxamine
Hydroxynefazodone
Ibogaine
Imipramine
Levomilnacipran
Levorphanol
Lumateperone
Fluvoxamine CR
Meperidine
Methadone
Milnacipran
Nefazodone
Nordoxepin
Norfluoxetine
Noribogaine
Nortriptyline
Paroxetine
Paroxetine CR
Pentazocine
Protriptyline
R-Methadone
Saffron
Sertraline
Doxepin low-dose (insomnia)
St John's wort
Tapentadol
Tramadol
Trazodone
Trimipramine
Tramadol ER
Venlafaxine
Vilazodone
Vortioxetine
Ziprasidone
Ziprasidone IM
Self-check
- How does SERT inhibition affect extracellular serotonin?
Increases it. - Which combination creates high serotonin-toxicity risk?
MAO inhibition plus SERT inhibition.
All mechanisms · Open SERT inhibitor in the interactive console ↗