Hydroxy nefazodone
nefazodone metabolite
What it isThe hydroxy metabolite of nefazodone, retaining the parent’s 5-HT2 antagonism.
Why it mattersIt contributes to nefazodone’s therapeutic effect while sharing its CYP3A4 inhibition.
What it changesIt does not explain the hepatotoxicity, which is attributed to a separate quinone-imine pathway.
FDA-approved for
- depression (metabolite of nefazodone)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Mechanism of action: Hydroxy nefazodone ballicule
