Centanafadine
SIMTRIYO
What it isNorepinephrine, dopamine, and serotonin reuptake inhibitor; ADHD.
Why this oneUnlike stimulants and atomoxetine, it combines all three monoamine-reuptake mechanisms in one ADHD drug.
What limits itPediatric suicidal ideation and abuse or misuse carry boxed warnings; MAO inhibitors are contraindicated.
FDA-approved for
- ADHD (adults and children 6 years and older weighing at least 20 kg) (2026)
⚠ BOXED WARNINGS
- Suicidal ideation and behavior in pediatric patients
- Abuse, misuse and addiction
Classes and tags
Clinical profile
Mechanism of action: Centanafadine ballicule
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Memory aids: mascots and interaction avatars
NDSRI: blocks norepinephrine, dopamine, and serotonin reuptake
NDSRI: NET = norepinephrine transporter; DAT = dopamine transporter; SERT = serotonin transporter
