8-OH-Amoxapine
amoxapine metabolite
What it isThe 8-hydroxy metabolite of amoxapine, retaining D2 antagonism and noradrenergic reuptake inhibition.
Why it mattersIt carries much of amoxapine’s antipsychotic activity, which is why a tricyclic causes extrapyramidal effects.
What it changesIt is why amoxapine can cause tardive dyskinesia — a risk not expected from an antidepressant.
FDA-approved for
- depression (metabolite of amoxapine)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Mechanism of action: 8-OH-Amoxapine ballicule
