Dextrorphan
dextromethorphan metabolite
What it isO-demethyl metabolite of dextromethorphan, a more potent NMDA antagonist than the parent.
Why it mattersProduces dextromethorphan’s dissociative effects; CYP2D6 ultra-rapid metabolizers therefore experience them at lower doses.
What it changesBlocking its formation with quinidine or bupropion is the basis of the dextromethorphan combination antidepressants.
Used for
- cough (metabolite of dextromethorphan)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
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Self-check
- How does dextrorphan NMDA potency compare with dextromethorphan?
More potent. - Which CYP2D6 phenotype can experience dissociation at lower doses?
Ultra-rapid metabolizers.