Desmethyl sertraline
sertraline metabolite
What it isThe N-desmethyl metabolite of sertraline, far weaker at SERT but with a much longer half-life.
Why it mattersIts weak activity is why sertraline has little accumulation effect despite a metabolite that persists three times longer.
What it changesIt contributes little clinically, which is part of why sertraline is predictable across patients.
FDA-approved for
- depression (metabolite of sertraline)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Mechanism of action: Desmethyl sertraline ballicule
