Saffron

What it isCrocus sativus stigma extract, studied as an herbal antidepressant.

Why this oneSmall randomized trials — several against SSRIs — repeatedly suggest efficacy in mild-to-moderate depression, making it one of the better-studied herbal psychotropics.

What limits itTrials are small, mostly from one region, and extract standardization varies; high doses are toxic and it is avoided in pregnancy.