Withdrawn from the market (safety)
Cisapride
PROPULSID
What it is5-HT4 agonist prokinetic; withdrawn.
Why this oneIt was the most effective prokinetic for gastroparesis and reflux.
What limits itWithdrawn for fatal QT arrhythmias, particularly with CYP3A4 inhibitors — the case that taught the field about drug-induced torsades.
FDA-approved for
- GERD (1993 — US market withdrawn 2000, limited-access only)
⚠ BOXED WARNING
- Serious cardiac arrhythmias including torsades
Classes and tags
Clinical profile
Mechanism of action: Cisapride ballicule
