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Withdrawn from the market (business decision)

Ethchlorvynol

PLACIDYL

What it isTertiary acetylenic alcohol sedative-hypnotic; withdrawn.

Why this oneIt was a widely used hypnotic before the benzodiazepines.

What limits itNarrow margin, dependence and a difficult overdose. US marketing discontinued in 1999.

FDA-approved for

NO BOXED WARNINGS

Principal riskWithdrawn; narrow margin and dependence

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Ethchlorvynol ballicule

Ethchlorvynol ballicule: receptor binding, kinetics and half-life diagram

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