S-Methadone
dextromethadone
What it isThe S-enantiomer of methadone, with NMDA antagonism but little mu activity.
Why this oneIt carries most of methadone’s hERG blockade, so it explains the QT risk without contributing analgesia.
What limits itThis asymmetry is the argument for using the R-enantiomer alone — the QT liability sits mainly in the inactive half.
FDA-approved for
- inactive enantiomer of methadone
NO BOXED WARNINGS
Principal riskThis asymmetry is the argument for using the R-enantiomer alone — the QT liability sits mainly i
Classes and tags
Clinical profile
Mechanism of action: S-Methadone ballicule
