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Dizocilpine

MK-801

What it isMK-801, the prototypical high-affinity NMDA channel blocker.

Why this oneIt is the reference compound that established NMDA blockade as a model of psychosis.

What limits itNeurotoxic vacuolization in animals ended development; a research tool only.

NO BOXED WARNINGS

Principal riskResearch tool; neurotoxic in animals

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Dizocilpine ballicule

Dizocilpine ballicule: receptor binding, kinetics and half-life diagram

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