Tocainide
TONOCARD
What it isOral class IB antiarrhythmic, a lidocaine analogue; withdrawn.
Why this oneIt offered oral lidocaine-like activity for ventricular arrhythmia.
What limits itAgranulocytosis and pulmonary fibrosis ended its use.
Tocainide prescription history
Animated chart of estimated U.S. prescriptions per year, Antiarrhythmics (class I/III) (1930–2026). Tocainide enters in 1985 (estimated).
FDA-approved for
- ventricular arrhythmias (withdrawn) (1984)
⚠ BOXED WARNINGS
- Agranulocytosis
- Pulmonary fibrosis
Classes and tags
Clinical profile
Defining liabilityPotentially fatal marrow and pulmonary toxicity
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Self-check
- Which IV antiarrhythmic did tocainide mimic orally?
Lidocaine. - Which toxicities ended tocainide use?
Agranulocytosis and pulmonary fibrosis.