Moricizine
ETHMOZINE
What it isClass I antiarrhythmic; withdrawn.
Why this oneIt was studied in CAST-II as a supposedly safer class I agent.
What limits itCAST-II found excess early mortality, confirming the class hazard. Withdrawn.
Moricizine prescription history
Animated chart of estimated U.S. prescriptions per year, Antiarrhythmics (class I/III) (1930–2026). Moricizine enters in 1990 (estimated).
FDA-approved for
- ventricular arrhythmias (withdrawn) (1990)
⚠ BOXED WARNING
- Proarrhythmia and excess mortality after myocardial infarction
Classes and tags
Clinical profile
Defining liabilityProarrhythmia and increased mortality after myocardial infarction
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Self-check
- What outcome ended moricizine’s CAST-II promise?
Excess early mortality. - What antiarrhythmic class was moricizine?
Class I.