hERG blocker

hERG potassium channel blocker

Class III antiarrhythmics
Psychiatric medications that prolong QT interval do so by blocking Kv11.1 (hERG)
➔ many antidepressants and antipsychotics
➔ TCAs prolong QT, but overdose danger is driven primarily by Na⁺ channel blockade → QRS widening & malignant arrhythmias

Drugs with this mechanism (121)

8-OH-Amoxapine Loxapine inhaled Ajmaline Amiodarone Amisulpride Amitriptyline Amoxapine Aripiprazole lauroxil LAI Aripiprazole lauroxil LAI Aripiprazole monohydrate LAI Aripiprazole monohydrate LAI Asenapine Asenapine transdermal Bedaquiline Chloroquine Chlorpromazine Chlorpromazine injection Cibenzoline Cisapride Citalopram Clarithromycin Clomipramine Clozapine Crizotinib Dasatinib Dehydro aripiprazole Desipramine Desmethyl clomipramine (Desmethyl-) mirtazapine Desmethyl sertraline Deutetrabenazine Diphenhydramine Diphenhydramine injection Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Dronedarone Droperidol Erythromycin Escitalopram Clozapine ODT Fluconazole Fluphenazine Fluphenazine decanoate LAI Gepirone Granisetron Haloperidol Haloperidol decanoate LAI Haloperidol injection Hydroquinidine Hydroxy chloroquine Hydroxy nefazodone Hydroxyzine HCl Hydroxyzine IM Hydroxyzine pamoate Ibutilide Iloperidone Imipramine Itraconazole Ketoconazole Levofloxacin Loperamide Loxapine Lurasidone Maprotiline Methadone Mianserin Milsaperidone Mirtazapine Mitragynine Moxifloxacin NAPA Nilotinib Norclozapine Nordoxepin Norquetiapine Olanzapine Olanzapine IM Olanzapine pamoate LAI Ondansetron Osimertinib Paliperidone Panobinostat Perphenazine Pimavanserin Pimozide Pitolisant Posaconazole Procainamide Prochlorperazine Promethazine Promethazine injection Protriptyline Quetiapine Quinidine Quizartinib R-Methadone Ranolazine Ribociclib Risperidone S-Methadone Quetiapine XR Sertraline Doxepin low-dose (insomnia) Sotalol Sulpiride Tetrabenazine Thioridazine Thiothixene Trazodone Trifluoperazine Trimipramine Valbenazine Vandetanib Clozapine oral suspension Voriconazole Ziprasidone Ziprasidone IM

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