Fluphenazine injection
PROLIXIN IM
Pronunciation: floo-FEN-a-zeen
“Prolix Fluffy hen”
What it isImmediate-acting fluphenazine HCl injection for acute psychosis: start 1.25 mg IM; usual 2.5–10 mg/day divided every 6–8 h; above 10 mg/day with caution.
Why this oneIM dose is about ⅓–½ the oral dose; switch to oral maintenance once symptoms are controlled. Not the decanoate depot.
What limits itBoxed warning: increased mortality in elderly patients with dementia-related psychosis. Contraindicated in coma, blood dyscrasias, liver damage and subcortical brain damage.
FDA-approved for
- psychotic disorders (~1959)
⚠ BOXED WARNING
- Increased mortality in elderly patients with dementia-related psychosis
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilityMetabolic effects, extrapyramidal symptoms/tardive dyskinesia and agent-specific QT or orthostatic risk.
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