Mitragynine
in kratom
What it isThe principal kratom alkaloid, a mu partial agonist biased away from beta-arrestin.
Why this oneIts biased signaling is the pharmacological basis for the claim of analgesia with less respiratory depression.
What limits itIts metabolite 7-hydroxymitragynine is far more potent, so concentrated products behave very differently from leaf.
FDA-approved for
- primary kratom alkaloid (not approved)
NO BOXED WARNINGS
Principal riskIts metabolite 7-hydroxymitragynine is far more potent, so concentrated products behave very dif
Classes and tags
Clinical profile
Active metabolites
Mechanism of action: Mitragynine ballicule
Open Mitragynine in the interactive console ↗
Memory aids: mascots and interaction avatars
