7-OH-mitragynine
kratom metabolite
What it isCYP3A4 oxidation metabolite of mitragynine; kratom’s principal mu-opioid full agonist, with roughly 5x the parent alkaloid’s mu-receptor affinity.
Why it mattersDrives most of kratom's analgesic, euphoric, and dependence-producing opioid effect. Concentrated synthetic 7-OH products prompted FDA warnings and a 2026 DEA move to Schedule I.
What it changesBecause it is generated by CYP3A4, strong 3A4 inhibitors or inducers shift its exposure, and its mu agonism carries real respiratory-depression and dependence risk, compounded by other opioids or sedatives.
NO BOXED WARNINGS
Classes and tags
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Self-check
- Which enzyme forms 7-OH-mitragynine?
CYP3A4. - How does its mu-receptor affinity compare with mitragynine?
Roughly 5x greater.