Olanzapine IM
ZYPREXA INTRAMUSCULAR
What it isInjectable second-generation antipsychotic (ZYPREXA INTRAMUSCULAR, 2004) with D2, 5-HT2A, histamine, muscarinic, and alpha-1 blockade; acute agitation.
Why this oneIt controls agitation with less acute dystonia than haloperidol while preserving olanzapine’s sedative effect.
What limits itAvoid close use with parenteral benzodiazepines because cardiorespiratory depression can occur; hypotension and oversedation limit use.
FDA-approved for
- acute agitation (schizophrenia, bipolar I mania) (2004)
⚠ BOXED WARNING
- Increased mortality in elderly patients with dementia-related psychosis
Classes and tags
Clinical profile
Mechanism of action: Olanzapine IM ballicule
