Mianserin
TOLVON
What it isTetracyclic alpha-2 antagonist; depression outside the US.
Why this oneThe predecessor of mirtazapine, sedating and without sexual dysfunction.
What limits itAgranulocytosis is more frequent than with mirtazapine. Not US-approved.
Used for
- depression (approved in Europe and Japan)
⚠ BOXED WARNING
- Suicidal thoughts and behaviors in patients under 25
Classes and tags
Clinical profile
Defining liabilityMarked sedation; potentially severe bone-marrow suppression
Open Mianserin in the interactive console ↗
Self-check
- How does mianserin’s agranulocytosis risk compare with mirtazapine’s?
More frequent. - Is mianserin US-approved?
No.