Dehydroaripiprazole
aripiprazole metabolite
What it isDehydro metabolite of aripiprazole, a D2 partial agonist with similar affinity and a longer half-life.
Why it mattersRepresents about 40% of total exposure, so aripiprazole’s effect is really the sum of two long-lived partial agonists.
What it changesIt is part of why aripiprazole takes two weeks to reach steady state and why akathisia can emerge late.
Used for
- schizophrenia/bipolar (metabolite of aripiprazole)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
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Self-check
- About what share of total aripiprazole exposure is dehydroaripiprazole?
40%. - Why can aripiprazole akathisia emerge late?
Long-lived parent/metabolite and delayed steady state.