Norquetiapine
quetiapine metabolite
“Nora, Quit typing!”
Crown → antihistamine
QT prolongation
Magical orb → NQTP is more relevant than QTP parent
What it isN-desalkylquetiapine, formed by CYP3A4, a norepinephrine reuptake inhibitor and 5-HT1A partial agonist.
Why it mattersCarries most of quetiapine’s antidepressant effect, which the parent’s receptor profile alone does not explain.
What it changesIt explains why quetiapine works in bipolar depression at doses well below the antipsychotic range.
Used for
- depression/psychosis (active metabolite of quetiapine)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Open Norquetiapine in the interactive console ↗
Memory aids: interaction avatars
Open Norquetiapine in the interactive console ↗
Self-check
- Which CYP forms norquetiapine?
CYP3A4. - What quetiapine effect is largely carried by norquetiapine?
Antidepressant effect.