Prochlorperazine injection

What it isProchlorperazine injection (5 mg/mL) is given deep IM or by slow IV (no faster than 5 mg/min, never as a bolus; single IV dose 10 mg or less); 2.5-10 mg for severe nausea and vomiting, total parenteral dose 40 mg/day or less.

Why this oneFor schizophrenia the label gives 10-20 mg IM initially, repeated every 2-4 hours if needed, then oral therapy once control is reached; onset within 10-20 minutes, effect 3-4 hours.

What limits itBoxed warning (antipsychotic class): increased mortality in elderly patients with dementia-related psychosis. Not for children under 2 years or under 20 lb, nor for pediatric surgery.