CNS depression

Interaction at a glance

• Suppresses arousal and/or respiratory drive

Clinical consequence

• Suppresses arousal and/or respiratory drive
• Sedatives, opioids + alcohol can synergize

Who is at greatest risk

• Respiratory disease and older age magnify danger
• “Sedation” may understate severe combinations

Clinical consequence / modifiers

• Falls, impaired driving + overdose risk rise

Self-check

• What is the main clinical risk of CNS depression?
  “Sedation” may understate severe combinations.
• What major clinical effect is associated with CNS depression?
  Falls, impaired driving + overdose risk rise.

Drugs in this interaction (66)

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