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Salvinorin A

salvia

What it isNon-nitrogenous kappa opioid agonist from Salvia divinorum.

Why this oneIt is the most potent naturally occurring hallucinogen and the only one acting through kappa rather than 5-HT2A.

What limits itIntense brief dissociation with a high risk of injury. No therapeutic use; it is the tool compound for kappa research.

FDA-approved for

NO BOXED WARNINGS

Principal riskIntense brief dissociation with a high risk of injury

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Salvinorin A ballicule

Salvinorin A ballicule: receptor binding, kinetics and half-life diagram

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