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DHEAS

neurosteroid

What it isThe sulfated, circulating storage form of DHEA and a GABA-A negative modulator.

Why this oneIts long half-life makes it the measured marker of adrenal androgen production.

What limits itIts GABA-A antagonism opposes allopregnanolone, so the two neurosteroids pull in opposite directions.

NO BOXED WARNINGS

Principal riskEndogenous or dietary; no boxed warning applies

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: DHEAS ballicule

DHEAS ballicule: receptor binding, kinetics and half-life diagram

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