Enoxacin
PENETREX
What it isFluoroquinolone; bacterial infection.
Why this oneLittle used, but pharmacologically notable as one of the strongest CYP1A2 inhibitors.
What limits itSeizure risk and the full quinolone liability. Largely withdrawn from use.
Enoxacin prescription history
Animated chart of estimated U.S. prescriptions per year, Quinolone antibacterials (1964–2026). Enoxacin enters in 1992 (estimated).
FDA-approved for
- bacterial infections (1991)
NO BOXED WARNINGS
Principal riskSeizure risk and the full quinolone liability
Classes and tags
Clinical profile
Defining liabilityTendon/CNS toxicity and potent CYP1A2 interactions
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Self-check
- Which CYP enzyme does enoxacin strongly inhibit?
CYP1A2. - Which neurologic toxicity is highlighted for enoxacin?
Seizures.