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Butalbital

in FIORICET

What it isBarbiturate combined with acetaminophen or aspirin and caffeine; tension and mixed headache.

Why this oneIt relieves refractory headache when simple analgesics have failed.

What limits itMedication-overuse headache develops quickly, and barbiturate dependence and withdrawal follow regular use. Most headache guidelines advise against it.

FDA-approved for

NO BOXED WARNINGS

Principal riskMedication-overuse headache and barbiturate dependence

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Butalbital ballicule

Butalbital ballicule: receptor binding, kinetics and half-life diagram

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Memory aids: mascots and interaction avatars

Butalbital FIORICET mascot mnemonic cartoon
“Butane Al (Fire setter)”
Barbs → barbiturate

Open Butalbital in the interactive console ↗