Butalbital

in FIORICET

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Pronunciation: byoo-TAL-bi-tal

Butalbital ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Butalbital ballicule

Butalbital FIORICET mascot mnemonic cartoon — Visual mnemonic: Butalbital mascot
**“Butane Al (Fire setter)”**
Barbs → barbiturate

What it isBarbiturate combined with acetaminophen or aspirin and caffeine; tension and mixed headache.

Why this oneRelieves refractory headache when simple analgesics have failed.

What limits itMedication-overuse headache develops quickly, and barbiturate dependence and withdrawal follow regular use. Most headache guidelines advise against it.

Butalbital molecular structure (skeletal formula) — Molecular structure: Butalbital

FDA-approved for

tension headache (combination products)

NO BOXED WARNINGS

Principal riskMedication-overuse headache and barbiturate dependence

Classes and tags

Clinical profile

Therapeutic safety burden3 / 4

Overdose danger2 / 4

Sedation liability2 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk3 / 4

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Self-check

What headache complication develops quickly with butalbital?
Medication-overuse headache.
What follows regular butalbital use?
Barbiturate dependence and withdrawal.