Pregnenolone
neurosteroid
What it isThe precursor from which all steroid hormones and neurosteroids are made.
Why this oneIts position at the head of the pathway is why it is marketed as a broad hormonal supplement.
What limits itSupplementation raises unpredictable downstream hormones. Evidence for the promoted uses is weak.
NO BOXED WARNINGS
Principal riskSupplementation raises unpredictable downstream hormones
Classes and tags
Clinical profile
Defining liabilityLimited long-term endocrine and reproductive safety evidence
Available strengths
- cap 10, 25, 50, 100 mg
Active metabolites
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Self-check
- Pregnenolone: What is its position in steroid synthesis?
Precursor of all steroid hormones and neurosteroids. - Pregnenolone: What makes supplementation unpredictable?
Unpredictable downstream hormone increases.