Androstanediol
3α-androstanediol
What it isEndogenous neurosteroid derived from dihydrotestosterone, a GABA-A positive modulator.
Why this oneLinks androgen levels to GABAergic tone—one route by which testosterone affects mood and anxiety.
What limits itExplains why 5-alpha reductase inhibitors can affect mood: they block its synthesis as well as DHT.
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies
Classes and tags
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Self-check
- From which androgen is androstanediol derived?
Dihydrotestosterone. - Why can 5-alpha reductase inhibitors affect mood?
They block androstanediol synthesis as well as DHT.