Phenibut
β-phenyl-GABA
What it isGABA-B agonist and alpha-2-delta ligand; sold as a supplement, prescribed in some countries.
Why this oneIt produces anxiolysis with GABA-B agonism, a mechanism no approved anxiolytic uses.
What limits it⚑ Severe dependence with a baclofen-like withdrawal syndrome including delirium and seizures. Unregulated content.
FDA-approved for
- anxiolytic/nootropic (non-US; not FDA-approved)
Off-label
- anxiety and insomnia (approved in Russia; sold as a supplement in the US)
NO BOXED WARNINGS
Principal riskSevere dependence with a baclofen-like withdrawal
Classes and tags
Clinical profile
Mechanism of action: Phenibut ballicule
