QTc prolongation
- Delays ventricular repolarization
- hERG/Ikr block is the classic mechanism
- Excess QTc can permit torsades de pointes
- Low K/Mg, bradycardia + drug stacking increase risk
- QRS widening is a separate contributor to QT
Interaction at a glance
- Delays ventricular repolarization
Mechanism
- Delays ventricular repolarization
- hERG/Ikr block is the classic mechanism
Clinical consequence
- Excess QTc can permit torsades de pointes
- Low K/Mg, bradycardia + drug stacking increase risk
Timing / washout
- QRS widening is a separate contributor to QT
Self-check
- What arrhythmia can excessive QTc prolongation permit?
Torsades de pointes.
- What factors increase QT-related risk?
Low K/Mg, bradycardia, and drug stacking.
Drugs in this interaction (190)
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