Omeprazole

PRILOSEC

What it isIrreversible proton-pump inhibitor for GERD, peptic ulcer disease and H. pylori regimens.

Why this oneIt is the most interaction-prone common PPI; pantoprazole is preferred when clopidogrel must remain effective.

What limits itLong-term use can deplete magnesium and B12 and raise fracture or enteric-infection risk; reassess the indication.

FDA-approved for

FDA dosing	Population	Start	Target	Max
Frequent heartburn (OTC, ≥2 days/week)	Adults ≥18 yr	1 capsule QD	1 capsule QD	1 capsule/day

Renal Undefined

Hepatic Undefined

Full effect may take 1-4 days; do not take more than 1 capsule a day

Swallow 1 capsule with a glass of water at least 1 hour before eating in the morning
Take every day for 14 days
Do not chew or crush; do not open capsule or sprinkle on food
Do not use for more than 14 days or more often than every 4 months unless directed by a doctor
May repeat a 14-day course every 4 months

Pregnancy Undefined

Lactation Undefined

NO BOXED WARNINGS

Principal riskLong-term use: B12 deficiency, hypomagnesemia, fracture

Cost, est. cash$300–$2,500/month

Generic entry2009