Hydroxybupropion
bupropion metabolite
What it isThe major active metabolite of bupropion, formed by CYP2B6, present at far higher concentrations than the parent.
Why it mattersMost of bupropion’s noradrenergic effect and much of its seizure risk are attributable to it rather than to bupropion.
What it changesCYP2B6 variation changes its level severalfold, which explains why bupropion response and tolerability vary so widely.
FDA-approved for
- depression/smoking cessation (metabolite of bupropion)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Mechanism of action: Hydroxybupropion ballicule
