Renal clearance (predominant)
- Kidney is the major route of drug elimination
- Reduced GFR can markedly raise exposure
- Dose/interval adjustment may be required
- Acute kidney injury can change levels quickly
- Dialyzability is a separate property
Interaction at a glance
- Kidney is the major route of drug elimination
Mechanism
- Acute kidney injury can change levels quickly
Timing / washout
- Reduced GFR can markedly raise exposure
- Dose/interval adjustment may be required
- Dialyzability is a separate property
Mechanism / modifiers
- Kidney is the major route of drug elimination
Self-check
- What does “Renal clearance (predominant)” mean?
Kidney is the major route of drug elimination.
Drugs in this interaction (211)
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