Renal clearance (predominant)
- Kidney is the major route of drug elimination
- Reduced GFR can markedly raise exposure
- Dose/interval adjustment may be required
- Acute kidney injury can change levels quickly
- Dialyzability is a separate property
Interaction at a glance
- Kidney is the major route of drug elimination
Mechanism
- Acute kidney injury can change levels quickly
Timing / washout
- Reduced GFR can markedly raise exposure
- Dose/interval adjustment may be required
- Dialyzability is a separate property
Mechanism / modifiers
- Kidney is the major route of drug elimination
Self-check
- Does predominant renal clearance establish dialyzability?
No; dialyzability is a separate property. - Can AKI change drug levels quickly?
Yes.
Drugs in this interaction (211)
All interaction examples · Open Renal clearance (predominant) in the interactive console ↗