1-PP
buspirone/gepirone metabolite
What it is1-(2-pyrimidinyl)piperazine, a metabolite of buspirone and gepirone, an alpha-2 antagonist.
Why it mattersIts noradrenergic effect may contribute to the activation and dizziness some patients feel on buspirone.
What it changesIt accumulates in renal impairment, which is one reason buspirone tolerability worsens there.
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Mechanism of action: 1-PP ballicule
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Memory aids: mascots and interaction avatars
resembles mirtazapine due to alpha-2A antagonist mechanism
