1-PP
buspirone/gepirone metabolite
“#1 (pee pee)”
resembles mirtazapine due to alpha-2A antagonist mechanism
What it is1-(2-pyrimidinyl)piperazine, a metabolite of buspirone and gepirone, an alpha-2 antagonist.
Why it mattersNoradrenergic effects may contribute to activation and dizziness in some patients taking buspirone.
What it changesIt accumulates in renal impairment, which is one reason buspirone tolerability worsens there.
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Open 1-PP in the interactive console ↗
Self-check
- When can 1-PP accumulate?
Renal impairment. - Which buspirone symptoms may 1-PP contribute to?
Activation and dizziness.