Thiamine
VITAMIN B1
What it isVitamin B1 cofactor for carbohydrate metabolism; thiamine deficiency and Wernicke encephalopathy.
Why this oneSuspected Wernicke encephalopathy is treated immediately without waiting for tests; glucose should not be delayed.
What limits itSevere deficiency needs parenteral replacement because oral absorption is unreliable; rare anaphylaxis warrants monitoring.
FDA-approved for
- thiamine deficiency
- Wernicke encephalopathy
NO BOXED WARNINGS
Principal riskrare anaphylaxis with parenteral administration
Cost, est. cash$20–$300/month
Generic entry1982
Classes and tags
Clinical profile
Legacy pregnancy categoryA
Defining liabilityUsually well tolerated at replacement doses; excessive dosing can cause agent-specific metabolic or organ toxicity.
Active metabolites
Mechanism of action: Thiamine ballicule
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alcoholism frequently leads to Vitamin B1 deficiency
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