Thiamine pyrophosphate
from thiamine
What it isThiamine pyrophosphate, the active coenzyme of vitamin B1.
Why it mattersCofactor for pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase: gatekeepers of carbohydrate oxidation.
What it changesGlucose before thiamine in a depleted patient consumes the last TPP and can precipitate Wernicke encephalopathy; banana-bag order matters.
NO BOXED WARNINGS
Classes and tags
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Self-check
- Which vitamin supplies the active coenzyme TPP?
Vitamin B1. - Name another TPP-dependent enzyme besides pyruvate dehydrogenase.
Alpha-ketoglutarate dehydrogenase.