Thiamine pyrophosphate
from thiamine
What it isThiamine pyrophosphate, the active coenzyme of vitamin B1.
Why it mattersIt is the cofactor for pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase — the gatekeepers of carbohydrate oxidation.
What it changesGlucose given before thiamine in a depleted patient consumes the last TPP and can precipitate Wernicke encephalopathy — the order of the banana bag matters.
NO BOXED WARNINGS
Classes and tags
Clinical profile
Mechanism of action: Thiamine pyrophosphate ballicule
